5-碘-1-甲基-1H-吡唑合成路线 （共 7 条）
反应条件
1: With (THF)Li(TMP)Zn(tBu)2 in tetrahydrofuran T=25°C; 1 h; Inert atmosphere; 2: With iodine in tetrahydrofuran T=25°C; 1 h; Inert atmosphere; regioselective reaction;
参考文献
Blair, Victoria L.; Blakemore, David C.; Hay, Duncan; Hevia, Eva; Pryde, David C.
Tetrahedron Letters, 2011 , vol. 52, # 36 p. 4590 - 4594
参考文献
Journal of Organic Chemistry, , vol. 49, # 24 p. 4687 - 4695
反应条件
1: 5-iodo-1-methylpyrazole With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 2 h; 2: With indium(III) chloride in tetrahydrofuran; pentane T=-78 - 20°C; 3: iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; pentane Heating; Further stages.;
参考文献
Font-Sanchis, Enrique; Cespedes-Guirao, F. Javier; Sastre-Santos, Angela; Fernandez-Lazaro, Fernando
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3589 - 3591
反应条件
1: thien-2-yl-lithium With indium(III) chloride in tetrahydrofuran
T=-78 - 20°C;
2: 5-iodo-1-methylpyrazole With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
Heating; Further stages.;
参考文献
Font-Sanchis, Enrique; Cespedes-Guirao, F. Javier; Sastre-Santos, Angela; Fernandez-Lazaro, Fernando
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3589 - 3591
反应条件
1: 5-iodo-1-methylpyrazole With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78°C; 2 h;
2: With indium(III) chloride in tetrahydrofuran; pentane
T=-78 - 20°C;
3: 2-Iodothiophene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; pentane
Heating; Further stages.;
参考文献
Font-Sanchis, Enrique; Cespedes-Guirao, F. Javier; Sastre-Santos, Angela; Fernandez-Lazaro, Fernando
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3589 - 3591
反应条件
1: 5-iodo-1-methylpyrazole With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78°C; 2 h;
2: With indium(III) chloride in tetrahydrofuran; pentane
T=-78 - 20°C;
3: 2-iodo-pyridine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; pentane
Heating; Further stages.;
参考文献
Font-Sanchis, Enrique; Cespedes-Guirao, F. Javier; Sastre-Santos, Angela; Fernandez-Lazaro, Fernando
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3589 - 3591
反应条件
1: 5-iodo-1-methylpyrazole With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78°C; 2 h;
2: With indium(III) chloride in tetrahydrofuran; pentane
T=-78 - 20°C;
3: 3-iodo-pyridine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; pentane
Heating; Further stages.;
参考文献
Font-Sanchis, Enrique; Cespedes-Guirao, F. Javier; Sastre-Santos, Angela; Fernandez-Lazaro, Fernando
Journal of Organic Chemistry, 2007 , vol. 72, # 9 p. 3589 - 3591
