1: 1.) BSA, TMSOTf / 1.) DCE, 2.) TolH 2: 87 percent / NH4OH / methanol / 48 h / 60 °C 3: 100 percent / adenosine deaminase, phosphate buffer / dimethylsulfoxide; H2O View Scheme

1: 5.4 g / triethylamine / dimethylformamide / 1.) r.t. 60 h; 2.) 40 deg C, 1 h 2: 85 percent / Na / methanol / 1.) reflux, 2 h; 2.) r.t. 12 h 3: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating 4: 18 h / 25 °C / adenosine deaminase, pH = 7.5 View Scheme

trimethylsilyl trifluoromethanesulfonate; ammonia; water; bis(trimethyl-silyl)acetamide 1.) acetonitrile, reflux, 2.5 h, 2.) MeOH, 80 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given;

trimethylsilyl trifluoromethanesulfonate; ammonia; water; bis(trimethyl-silyl)acetamide 1.) acetonitrile, reflux, 2.5 h, 2.) MeOH, 80 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given;

1: 5.4 g / triethylamine / dimethylformamide / 1.) r.t. 60 h; 2.) 40 deg C, 1 h 2: 85 percent / Na / methanol / 1.) reflux, 2 h; 2.) r.t. 12 h 3: 80 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating View Scheme

1: 1.) BSA, TMSOTf / 1.) DCE, 2.) TolH 2: 87 percent / NH4OH / methanol / 48 h / 60 °C 3: 100 percent / adenosine deaminase, phosphate buffer / dimethylsulfoxide; H2O 4: 92 percent / methanol View Scheme

1: 5.4 g / triethylamine / dimethylformamide / 1.) r.t. 60 h; 2.) 40 deg C, 1 h 2: 85 percent / Na / methanol / 1.) reflux, 2 h; 2.) r.t. 12 h 3: 200 mg / 60percent HF in pyridine / 0.25 h / -40 - -30 °C 4: 88 percent / palladium oxide, cyclohexene / ethanol / 3 h / Heating View Scheme