1-溴-4-氟萘合成路线

参考文献

Lowe III, John A.; Qian, Weimin; Drozda, Susan E.; Volkmann, Robert A.; Nason, Deane; Nelson, Robert B.; Nolan, Charles; Liston, Dane; Ward, Karen; Faraci, Steve; Verdries, Kim; Seymour, Pat; Majchrzak, Michael; Villalobos, Anabella; White, W. Frost
Journal of Medicinal Chemistry, 2004 , vol. 47, # 6 p. 1575 - 1586

56-23-5四氯化碳+

321-38-01-氟萘+

7726-95-6溴

341-41-31-溴-4-氟萘

参考文献

Justus Liebigs Annalen der Chemie, , vol. 487, p. 270,282

341-41-31-溴-4-氟萘

573-03-54-氟-1-萘甲酸

参考文献

Adcock,W.; Dewar,M.J.S.
Journal of the American Chemical Society, 1967 , vol. 89, p. 386 - 390

341-41-31-溴-4-氟萘+

544-92-3氰化亚铜

13916-99-94-氟萘-1-甲腈

参考文献

Adcock,W.; Dewar,M.J.S.
Journal of the American Chemical Society, 1967 , vol. 89, p. 386 - 390

341-41-31-溴-4-氟萘

13772-56-04-氟-1-萘酸甲酯

参考文献

Adcock,W.; Dewar,M.J.S.
Journal of the American Chemical Society, 1967 , vol. 89, p. 386 - 390

341-41-31-溴-4-氟萘

17318-09-11-氟-4-碘萘

参考文献

MERCK and CO., INC.
Patent: WO2008/54675 A2, 2008 ;
Location in patent: Page/Page column 47 ;
WO 2008/054675 A2

150-46-9硼酸三乙酯+

341-41-31-溴-4-氟萘

182344-25-84-氟萘-1-硼酸

参考文献

Lowe III, John Adams
Patent: US2001/49379 A1, 2001 ;

182344-25-84-氟萘-1-硼酸

参考文献

Pfizer Inc
Patent: US6211208 B1, 2001 ;

341-41-31-溴-4-氟萘

182344-25-84-氟萘-1-硼酸

参考文献

Lowe III, John A.; Qian, Weimin; Drozda, Susan E.; Volkmann, Robert A.; Nason, Deane; Nelson, Robert B.; Nolan, Charles; Liston, Dane; Ward, Karen; Faraci, Steve; Verdries, Kim; Seymour, Pat; Majchrzak, Michael; Villalobos, Anabella; White, W. Frost
Journal of Medicinal Chemistry, 2004 , vol. 47, # 6 p. 1575 - 1586

383-63-1三氟乙酸乙酯+

341-41-31-溴-4-氟萘

664364-14-1

参考文献

Takeda Pharmaceutical Company Limited
Patent: EP1553074 A1, 2005 ;
Location in patent: Page/Page column 50 ;