1: 1.) NaH / 1.) DMF, -10 deg C, 30 min, 2.) DMF, -15 deg C, 30 min 2: 29 percent / H2O / 5 h / 150 °C 3: 58 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 18 h / Ambient temperature 4: 96 percent / 2N aq. HCl / methanol / 2 h / Heating View Scheme
参考文献
Tanis, Steven P.; Parker, Timothy T.; Colca, Jerry R.; Fisher, Roberta M.; Kletzein, Rolf F.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5053 - 5063