3,6-二氯吡嗪-4-羧酸乙酯合成路线 （共 5 条）
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in tetrahydrofuran 0.833333 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2008/130951 A1, 2008 ;
Location in patent: Page/Page column 81 ;
WO 2008/130951 A1
反应条件
1: 8.1 g / K2Cr2O7, conc. H2SO4 / 2 h / 35 - 40 °C 2: 61 percent / (dimethylamino)pyridine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Obshchestvo S Ogranichennoy Otvetstvennostyou "Fusion Pharma"; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich
Patent: EP2743266 A2, 2014 ;
反应条件
1: in methanol T=20°C; 3.25 h; 2: With ammonia in water T=0°C; 24 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/108707 A1, 2004 ;
Location in patent: Page 54 ;
WO 2004/108707 A1
反应条件
1: in methanol
T=20°C; 3.25 h;
2: With ammonia in water
T=0°C; 24 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/108707 A1, 2004 ;
Location in patent: Page 54 ;
WO 2004/108707 A1
反应条件
1: hydrazine hydrate / water; ethanol; tetrahydrofuran
2: ethyl acetate
View Scheme
参考文献
Obshchestvo S Ogranichennoy Otvetstvennostyou "Fusion Pharma"; CHILOV, Germes Grigorievich; TITOV, Ilya Yurievich
Patent: EP2743266 A2, 2014 ;
