3-氰基-4-羟基苯甲酸乙酯合成路线 （共 9 条）
反应条件
in dimethyl sulfoxide T=100°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/73789 A1, 2008 ;
Location in patent: Page/Page column 5 ;
WO 2008/073789 A1
反应条件
palladium 10 on activated carbon; hydrogen in ethanol P=2585.81 Torr; 15 h;
参考文献
Zou, Mu-Fa; Cao, Jianjing; Rodriguez, Alice L.; Jeffrey Conn; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 9 p. 2650 - 2654
反应条件
in dimethyl sulfoxide T=100 - 120°C;
参考文献
Gorvin, John H.
Journal of Chemical Research, Miniprint, 1991 , # 4 p. 738 - 762
反应条件
in dimethyl sulfoxide
参考文献
Burroughs Wellcome Co.
Patent: US3933807 A1, 1976 ;
反应条件
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux 2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr View Scheme
参考文献
Zou, Mu-Fa; Cao, Jianjing; Rodriguez, Alice L.; Jeffrey Conn; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 9 p. 2650 - 2654
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr View Scheme
参考文献
Zou, Mu-Fa; Cao, Jianjing; Rodriguez, Alice L.; Jeffrey Conn; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 9 p. 2650 - 2654
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 2: water; sodium hydroxide / ethanol / 3 h / 50 °C 3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux 4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 5: palladium 10 on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr View Scheme
参考文献
Zou, Mu-Fa; Cao, Jianjing; Rodriguez, Alice L.; Jeffrey Conn; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 9 p. 2650 - 2654
反应条件
1: water; sodium hydroxide / ethanol / 3 h / 50 °C 2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux 3: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 4: palladium 10 on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr View Scheme
参考文献
Zou, Mu-Fa; Cao, Jianjing; Rodriguez, Alice L.; Jeffrey Conn; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 9 p. 2650 - 2654
反应条件
1: potassium carbonate / acetone / Reflux 2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere 3: water; sodium hydroxide / ethanol / 3 h / 50 °C 4: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux 5: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 6: palladium 10 on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr View Scheme
参考文献
Zou, Mu-Fa; Cao, Jianjing; Rodriguez, Alice L.; Jeffrey Conn; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 9 p. 2650 - 2654
