4-羟基-3,5-二甲基苯甲酸甲酯合成路线 （共 12 条）
反应条件
thionyl chloride T=20°C; 16 h; Cooling with ice;
参考文献
SIEMENS HEAL THCARE DIAGNOSTICS INC.; NATRAJAN, Anand; WEN, David
Patent: WO2014/11762 A1, 2014 ;
Location in patent: Paragraph 0107; 0108; 0109 ;
反应条件
sulfuric acid in methanol
参考文献
Sterling Winthrop Inc.
Patent: US5464848 A1, 1995 ;
US 5464848 A
反应条件
1: 34 percent / NaH 2: 92 percent / SOCl2 View Scheme
参考文献
Lu, Yixin; Lum, Tze Keong; Augustine, Yoon Wui Leow; Weltrowska, Grazyna; Nguyen, Thi M.-D.; Lemieux, Carole; Chung, Nga N.; Schiller, Peter W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 17 p. 5382 - 5385
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C 1.2: 41 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.1: 97 percent / H2SO4 / 15 h / Heating View Scheme
参考文献
Lu, Yixin; Lum, Tze Keong; Augustine, Yoon Wui Leow; Weltrowska, Grazyna; Nguyen, Thi M.-D.; Lemieux, Carole; Chung, Nga N.; Schiller, Peter W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 17 p. 5382 - 5385
反应条件
1: thionyl chloride / methanol / Inert atmosphere; Cooling 2: 48 h / 20 °C / Inert atmosphere View Scheme
参考文献
Natrajan, Anand; Sharpe, David; Wen, David
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 17 p. 3432 - 3447
反应条件
in tetrahydrofuran; diethyl ether T=0°C;
参考文献
Naganawa, Atsushi; Matsui, Toshiaki; Ima, Masaki; Yoshida, Koji; Tsuruta, Hiroshi; Yamamoto, Shingo; Yamamoto, Hiroshi; Okada, Hiroki; Maruyama, Takayuki; Nakai, Hisao; Kondo, Kigen; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7774 - 7789
反应条件
T=20°C; 48 h; Inert atmosphere;
参考文献
Natrajan, Anand; Sharpe, David; Wen, David
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 17 p. 3432 - 3447
反应条件
1: dimethylformamide 2: (i) (hydrolysis), (ii) /BRN= 1098229/, H2SO4 View Scheme
参考文献
Fujio,M. et al.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 2127 - 2133
反应条件
(i) (hydrolysis), (ii) /BRN= 1098229/, H2SO4; Multistep reaction;
参考文献
Fujio,M. et al.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 2127 - 2133
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1 h;
参考文献
Naganawa, Atsushi; Matsui, Toshiaki; Ima, Masaki; Yoshida, Koji; Tsuruta, Hiroshi; Yamamoto, Shingo; Yamamoto, Hiroshi; Okada, Hiroki; Maruyama, Takayuki; Nakai, Hisao; Kondo, Kigen; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7774 - 7789
