反应条件
1: ethyl (2RS,3SR)-3-methylpropanoate; formic acid ethyl ester With potassium tert-butylate in tetrahydrofuran; diethyl ether T=20°C; 3 h; Inert atmosphere; 2: thiourea in isopropyl alcohol Reflux; 3: With acetic acid in water pH=4;
参考文献
GLAXO GROUP LIMITED; JIN, Yun; WAN, Zehong; ZHANG, Qing
Patent: WO2012/76435 A1, 2012 ;
Location in patent: Page/Page column 49 ;