2-溴-6-(1,3-二氧戊环-2-基)吡啶合成路线 （共 6 条）
反应条件
toluene-4-sulfonic acid in benzene 2 h; Heating;
参考文献
Nimitz, Jonathan S.
Synthetic Communications, 1981 , vol. 11, # 4 p. 273 - 280
反应条件
toluene-4-sulfonic acid in hexane; dichloromethane; ethylene glycol; ethyl acetate; toluene
参考文献
Pfizer Inc
Patent: US2004/176390 A1, 2004 ;
反应条件
1.1: n-BuLi / diethyl ether; hexane / 0.08 h / -78 °C 1.2: diethyl ether; hexane / -78 - -10 °C 2.1: 78 percent / p-TsOH / benzene / 16 h / Heating View Scheme
参考文献
Davies, Stephen R.; Mitchell, Michael C.; Cain, Christopher P.; Devitt, Paul G.; Taylor, Roger J.; Kee, Terence P.
Journal of Organometallic Chemistry, 1998 , vol. 550, # 1-2 p. 29 - 57
反应条件
NiII chloride hexahydrate; iodine; acetic acid; lithium chloride; zinc in N,N-dimethyl-formamide
T=50 - 70°C; 6 h;
参考文献
Liao, Lian-Yan; Kong, Xing-Rui; Duan, Xin-Fang
Journal of Organic Chemistry, 2014 , vol. 79, # 2 p. 777 - 782
反应条件
1: n-BuLi / diethyl ether; tetrahydrofuran; hexane / 1.) -20 deg C, 10 min; -40 deg C, 15 min, 2.) -40 deg C to r.t., overnight
2: 2 M aq. HCl / 3 h / 60 °C
View Scheme
参考文献
Heirtzler, Fenton R.; Neuburger, Markus; Zehnder, Margareta; Constable, Edwin C.
Liebigs Annales, 1997 , # 2 p. 297 - 301
反应条件
1: 30 percent / NiCl2(PPh3)2, Zn, NEt4I / tetrahydrofuran
2: 77 percent / aq. HCl
View Scheme
参考文献
Falk, H.; Suste, A.
Monatshefte fuer Chemie, 1993 , vol. 124, # 8-9 p. 881 - 892
