5-溴-2,3-二羟基吡啶合成路线 （共 4 条）
反应条件
hydrogenchloride; aminosulfonic acid; bromine
参考文献
Journal of medicinal chemistry, , vol. 41, # 26 p. 5265 - 5271
反应条件
1: 17 percent / K2CO3 / dimethylformamide / 24 h / 100 °C 2: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) 1 h, -60 deg C View Scheme
参考文献
Dallacker; Jouck
1984 , vol. 39, # 11 p. 1598 - 1606
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one T=90°C; 16 h;
参考文献
H. Lundbeck A/S; Eskildsen, Jørgen; Sams, Anette Graven; Püschl, Ask
Patent: US2013/12530 A1, 2013 ;
Location in patent: Paragraph 0186 ;
US 20130012530 A1
参考文献
McElhinney; Donnelly; McCormick; Kelly; Watson; Rafferty; Elder; Middleton; Willington; McMurry; Margison
Journal of medicinal chemistry, 1998 , vol. 41, # 26 p. 5265 - 5271
