6-(4-甲基哌嗪-1-基)-4-(2-甲基苯基)烟酰胺合成路线 （共 13 条）
反应条件
1: methanol / 20.25 h / 18 - 25 °C 2: hydrogen; triethylamine; 20 palladium(II) hydroxide on carbon / methanol / 10 h / 25 °C / 2223.8 - 2497.89 Torr 3: sulfuric acid / toluene / 12 h / 70 °C View Scheme
参考文献
Harrington, Peter J.; Johnston, Dave; Moorlag, Henk; Wong, Jim-Wah; Hodges, L. Mark; Harris, Les; McEwen, Gerald K.; Smallwood, Blair
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1157 - 1166
反应条件
1: 4 h / 100 °C 2: MeSO3H / 5 h / 100 °C View Scheme
参考文献
Harrington, Peter J.; Johnston, Dave; Moorlag, Henk; Wong, Jim-Wah; Hodges, L. Mark; Harris, Les; McEwen, Gerald K.; Smallwood, Blair
Organic Process Research and Development, 2006 , vol. 10, # 6 p. 1157 - 1166
反应条件
1: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C 2: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C 3: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 5 p. 2000 - 2008
