9-[4-(叠氮基甲基)-2,2-二甲基-3a,4,6,6a-四氢呋喃并[3,4-d][1,3]二氧杂环戊烯-6-基]嘌呤-6-胺合成路线 （共 14 条）
反应条件
1: 88 percent / NH3/EtOH / 1.5 h 2: 84 percent / NaN3 / dimethylformamide / 45 h / 80 °C 3: 66 percent / NH3, MeOH / 40 h / Ambient temperature View Scheme
参考文献
Ceulemans; Vandendriessche; Rozenski; Herdewijn
Nucleosides and Nucleotides, 1995 , vol. 14, # 1-2 p. 117 - 127
反应条件
2: pyridine / 2 h / 0 °C 3: Ambient temperature 4: 88 percent / NH3/EtOH / 1.5 h 5: 84 percent / NaN3 / dimethylformamide / 45 h / 80 °C 6: 66 percent / NH3, MeOH / 40 h / Ambient temperature View Scheme
参考文献
Ceulemans; Vandendriessche; Rozenski; Herdewijn
Nucleosides and Nucleotides, 1995 , vol. 14, # 1-2 p. 117 - 127
反应条件
palladium 10 on activated carbon; hydrogen in ethanol T=20°C; 16 h;
参考文献
Moreau, Christelle; Kirchberger, Tanja; Swarbrick, Joanna M.; Bartlett, Stephen J.; Fliegert, Ralf; Yorgan, Timur; Bauche, Andreas; Harneit, Angelika; Guse, Andreas H.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 10079 - 10102
反应条件
trifluoroacetic acid in water
T=20°C; 0.333333 h;
参考文献
Comstock, Lindsay R; Rajski, Scott R
Tetrahedron, 2002 , vol. 58, # 30 p. 6019 - 6026
