5-脱氧-5-(甲基氨基)-2,3-O-(1-甲基亚乙基)-腺苷酸合成路线 (共 6 条)
反应条件
caesium carbonate; thiophenol in acetonitrile 18 h;
参考文献
Joce, Catherine; Caryl, Jamie; Stockley, Peter G.; Warriner, Stuart; Nelson, Adam
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 4 p. 635 - 638
参考文献
McCloskey, Diane E.; Bale, Shridhar; Secrist III, John A.; Tiwari, Anita; Moss III, Thomas H.; Valiyaveettil, Jacob; Brooks, Wesley H.; Guida, Wayne C.; Pegg, Anthony E.; Ealick, Steven E.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 5 p. 1388 - 1407
反应条件
72 h; Ambient temperature;
参考文献
Davis, Michael; Dudman, Nicholas P. B.; White, Hume F.
Australian Journal of Chemistry, 1983 , vol. 36, # 8 p. 1623 - 1627
反应条件
1: thionyl chloride 2: 0.392 g / Heating View Scheme
参考文献
Marasco Jr., Canio J.; Kramer, Debora L.; Miller, John; Porter, Carl W.; Bacchi, Cyrus J.; Rattendi, Donna; Kucera, Louis; Iyer, Nathan; Bernacki, Ralph; Pera, Paula; Sufrin, Janice R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5112 - 5122
参考文献
Marasco Jr., Canio J.; Kramer, Debora L.; Miller, John; Porter, Carl W.; Bacchi, Cyrus J.; Rattendi, Donna; Kucera, Louis; Iyer, Nathan; Bernacki, Ralph; Pera, Paula; Sufrin, Janice R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5112 - 5122
反应条件
sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane
T=20°C;
参考文献
EPIZYME, INC.; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; PATANE, Michael, A.
Patent: WO2012/82436 A2, 2012 ;
Location in patent: Page/Page column 141 ;
WO 2012/082436 A2