2-(5-溴吡啶-3-基)噁唑合成路线 (共 2 条)
反应条件
1: With sulfuric acid; phosphorus pentoxide T=20 - 100°C; 2: With ammonia in water T=0°C; pH=8;
参考文献
Merck and Co., Inc.
Patent: US6642237 B1, 2003 ;
Location in patent: Page/Page column 152-153 ;
反应条件
1: toluene / 2.5 h / |Reflux 2: sulfuric acid; phosphorous pentoxide / 0.5 h / 0 - 100 °C / pH Ca. 8 View Scheme
参考文献
MERCK SHARP and DOHME CORP.; GILBERT, Eric, J.; CUMMING, Jared, N.; STAMFORD, Andrew, W.; YU, Younong; SCOTT, Jack, D.; ISERLOH, Ulrich; WANG, Lingyan; CALDWELL, John, P.
Patent: WO2014/62553 A1, 2014 ;