(S)-2-苄氧基羰基氨基-4,4-二氟丁酸甲酯合成路线 （共 3 条）
反应条件
hydrogen; [Rh(COD)(S,S)-Et-Duphos)](+)*CF3SO3(-) in methanol P=2844.39 Torr; 15 h;
参考文献
Hu, Zilun; Han, Wei
Tetrahedron Letters, 2008 , vol. 49, # 5 p. 901 - 902
反应条件
hydrogen; [Rh(COD)(R,R)-Et-Duphos)](+)*CF3SO3(-) in methanol P=2844.39 Torr; 15 h; Title compound not separated from byproducts.;
参考文献
Hu, Zilun; Han, Wei
Tetrahedron Letters, 2008 , vol. 49, # 5 p. 901 - 902
反应条件
1.1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 0.33 h / -78 °C 1.2: 0.5 h / -78 °C 2.1: (+)-1,2-bis((2S, 5S)-2,5-diethylphospholano)benzene (cyclooctadiene)rhodium(I) trifluoromethanesulfonate / methanol / 0.08 h / |Inert atmosphere 2.2: 12 h / 7757.43 Torr View Scheme
参考文献
PORTOLA PHARMACEUTICALS, INC.; JIA, Zhaozhong J.; KANE, Brian; XU, Qing; BAUER, Shawn M.; SONG, Yonghong; PANDEY, Anjali; DICK, Ryan
Patent: WO2013/78468 A1, 2013 ;
