3-(3-溴苯基)-4H-1,2,4-噻唑合成路线 （共 5 条）
反应条件
hydrazine hydrate in acetic acid; N,N-dimethyl-formamide dimethyl acetal
参考文献
MERCK SHARP and DOHME CORP.; YOUNG, Jonathan; CZAKO, Barbara; ALTMAN, Michael; GUERIN, David; MARTINEZ, Michelle; RIVKIN, Alexey; WILSON, Kevin; LIPFORD, Kathryn; WHITE, Catherine; SURDI, Laura; CHICHETTI, Stephanie; DANIELS, Matthew, H.; AHEARN, Sean, P.; FALCONE, Danielle; OSIMBONI, Ekundayo
Patent: WO2011/84402 A1, 2011 ;
反应条件
hydrazine hydrate in DMF-DMA; acetic acid
参考文献
Smithkline Beecham Corporation
Patent: US2011/124559 A1, 2011 ;
反应条件
hydrazinium monoacetate; acetic acid T=95°C; 0.5 h;
参考文献
MERCK SHARP and DOHME CORP.; YOUNG, Jonathan; CZAKO, Barbara; ALTMAN, Michael; GUERIN, David; MARTINEZ, Michelle; RIVKIN, Alexey; WILSON, Kevin; LIPFORD, Kathryn; WHITE, Catherine; SURDI, Laura; CHICHETTI, Stephanie; DANIELS, Matthew, H.; AHEARN, Sean, P.; FALCONE, Danielle; OSIMBONI, Ekundayo
Patent: WO2011/84402 A1, 2011 ;
Location in patent: Page/Page column 146-147 ;
反应条件
1: T=100°C; 6 h; 2: With acetic acid; hydrazine T=20°C; 1 h;
参考文献
SIGNAL PHARMACEUTICALS, LLC
Patent: WO2008/51493 A2, 2008 ;
Location in patent: Page/Page column 165 ;
反应条件
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 - 20 °C / Inert atmosphere 1.2: 6 h / 10 °C 2.1: 0.5 h / 90 °C 3.1: hydrazinium monoacetate; acetic acid / 0.5 h / 95 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; YOUNG, Jonathan; CZAKO, Barbara; ALTMAN, Michael; GUERIN, David; MARTINEZ, Michelle; RIVKIN, Alexey; WILSON, Kevin; LIPFORD, Kathryn; WHITE, Catherine; SURDI, Laura; CHICHETTI, Stephanie; DANIELS, Matthew, H.; AHEARN, Sean, P.; FALCONE, Danielle; OSIMBONI, Ekundayo
Patent: WO2011/84402 A1, 2011 ;
