lithium hydroxide in methanol 2 h; Ambient temperature;

1: CuI, NaI, K2CO3 / dimethylformamide / 5 h / 20 °C 2: K2CO3, methanol / 4.5 h / 20 °C 3: CBr4, PPh3 / CH2Cl2 / 0 °C 4: CuI, NaI, K2CO3 / dimethylformamide / 5 h / 20 °C 5: 89 percent / 5percent aq. LiOH / methanol / 2 h / Ambient temperature View Scheme

1: CBr4, PPh3 / CH2Cl2 / 0 °C 2: CuI, NaI, K2CO3 / dimethylformamide / 5 h / 20 °C 3: 89 percent / 5percent aq. LiOH / methanol / 2 h / Ambient temperature View Scheme

1: CuI, NaI, K2CO3 / dimethylformamide / 5 h / 20 °C 2: 89 percent / 5percent aq. LiOH / methanol / 2 h / Ambient temperature View Scheme