乙基5-羟基-2-甲基苯甲酸酯合成路线 （共 9 条）
反应条件
1: With sulfuric acid in water T=0°C; 0.25 h; 2: With sulfuric acid; water; sodium nitrite T=0 - 60°C; 18.5 h;
参考文献
The Government of the United States of America, as represented by the Secretary, Department of HHS; Albany Molecular Research, Inc.; Science Applications International Corporation
Patent: US2009/312323 A1, 2009 ;
Location in patent: Page/Page column 17 ;
反应条件
1: With AlCl3, aluminium chloride in dichloromethane T=18 - 20.5°C; 1.41667 h; 2: With water in dichloromethane T=0°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/150119 A1, 2009 ;
Location in patent: Page/Page column 18-19 ;
反应条件
AlCl3 in dichloromethane
参考文献
MERRELL DOW PHARMACEUTICALS INC.
Patent: EP451422 A1, 1991 ;
反应条件
1: 94 percent / H2SO4 2: 100 percent / H2 / Pd/C / ethanol / Ambient temperature 3: 1.) NaNO3, H2SO4, 2.) Cu(NO3)2*2.5H2O, Cu2O / 1.) H2O, 0 deg C, 2.) H2O, rt View Scheme
参考文献
Della Sala, Giorgio; Izzo, Irene; De Riccardis, Francesco; Sodano, Guido
Tetrahedron Letters, 1998 , vol. 39, # 26 p. 4741 - 4744
反应条件
1: 100 percent / H2 / Pd/C / ethanol / Ambient temperature 2: 1.) NaNO3, H2SO4, 2.) Cu(NO3)2*2.5H2O, Cu2O / 1.) H2O, 0 deg C, 2.) H2O, rt View Scheme
参考文献
Della Sala, Giorgio; Izzo, Irene; De Riccardis, Francesco; Sodano, Guido
Tetrahedron Letters, 1998 , vol. 39, # 26 p. 4741 - 4744
反应条件
trifluoroacetic acid
参考文献
Marx,J.N. et al.
Journal of the American Chemical Society, 1974 , vol. 96, p. 2121 - 2129
参考文献
Einhorn; Pfyl
Justus Liebigs Annalen der Chemie, 1900 , vol. 311, p. 55
参考文献
Marx,J.N. et al.
Journal of the American Chemical Society, 1974 , vol. 96, p. 2121 - 2129
反应条件
1: ethyl 3-hydroxy-6-methylbenzoate With sodium hydride in N,N-dimethyl-formamide
T=20°C; 3.16667 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C;
参考文献
The United States of America, as represented by the Secretary, Department of Health and Human Services; Science Applications International Corporation (SAIC); Albany Molecular Research, Inc.
Patent: WO2009/42907 A1, 2009 ;
Location in patent: Page/Page column 35 ;
WO 2009/042907 A1
