22-(2-甲基-2-丙烯-1-基)-14-氧杂-11,22-二氮杂七环[13.9.1.01,13.02,21.04,12.05,10.019,25]二十五-4(12),5,7,9,15(25),16,18-七烯-2,16-二醇盐酸盐(1:1)合成路线 （共 2 条）
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342884-62-222-(2-甲基-2-丙烯-1-基)-14-氧杂-11,22-二氮杂七环[13.9.1.01,13.02,21.04,12.05,10.019,25]二十五-4(12),5,7,9,15(25),16,18-七烯-2,16-二醇盐酸盐(1:1)
反应条件
hydrogenchloride in methanol T=80°C; 12 h;
参考文献
Ullrich; Dersch; Rothman; Jacobson; Rice
Bioorganic and medicinal chemistry letters, 2001 , vol. 11, # 21 p. 2883 - 2885
→
342884-62-222-(2-甲基-2-丙烯-1-基)-14-氧杂-11,22-二氮杂七环[13.9.1.01,13.02,21.04,12.05,10.019,25]二十五-4(12),5,7,9,15(25),16,18-七烯-2,16-二醇盐酸盐(1:1)
反应条件
1: 85 percent / NaHCO3 / dimethylformamide / 2 h / 80 °C 2: 97 percent / 3 N HCl / methanol / 12 h / 80 °C View Scheme
参考文献
Ullrich; Dersch; Rothman; Jacobson; Rice
Bioorganic and medicinal chemistry letters, 2001 , vol. 11, # 21 p. 2883 - 2885
