甲基1-{[(2-甲基-2-丙基)氧基]羰基}-L-脯氨酰甘氨酸酯合成路线 （共 14 条）
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in dichloromethane 16 h;
参考文献
Ghalit, Nourdin; Poot, Alex J.; Fuerstner, Alois; Rijkers, Dirk T. S.; Liskamp, Rob M. J.
Organic Letters, 2005 , vol. 7, # 14 p. 2961 - 2964
反应条件
benzotriazol-1-ol; dicyclohexyl-carbodiimide in tetrahydrofuran cooling;
参考文献
Babu, V.V. Suresh; Tantry
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 12 p. 2708 - 2712
反应条件
1: pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester With 1-hydroxybenzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in DMF (N,N-dimethyl-formamide); dichloromethane T=0°C; 0.5 h; 2: glycine methylester hydrochloride With N-ethyl-N,N-diisopropylamine in DMF (N,N-dimethyl-formamide); dichloromethane T=0 - 20°C; 26 h;
参考文献
Novo Nordisk A/S
Patent: WO2003/104235 A1, 2003 ;
Location in patent: Page 23 ;
WO 03/104235 A1
反应条件
1: N,N-diisopropylethylamine; [bis(2-methoxyethyl)amino]sulfur trifluoride / CH2Cl2 / 0 °C 2: CH2Cl2 / 6.25 h / 0 - 20 °C View Scheme
参考文献
Srinivas, Deekonda; Vijayadas, Kuruppanthara N.; Gonnade, Rajesh; Phalgune, Usha D.; Rajamohanan, Pattuparambil R.; Sanjayan, Gangadhar J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 16 p. 5762 - 5765
反应条件
in dichloromethane T=0 - 20°C; 6.25 h;
参考文献
White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576
反应条件
in dichloromethane 5 h;
参考文献
Srinivas, Deekonda; Vijayadas, Kuruppanthara N.; Gonnade, Rajesh; Phalgune, Usha D.; Rajamohanan, Pattuparambil R.; Sanjayan, Gangadhar J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 16 p. 5762 - 5765
反应条件
1: 18-crown-6 2: 18-crown-6 View Scheme
参考文献
Mazurov, A. A.; Kabanov, V. M.; Andronati, S. A.
Doklady Chemistry, 1989 , vol. 306, # 1-3 p. 154 - 155
Dokl. Akad. Nauk SSSR Ser. Khim., 1989 , vol. 306, # 2 p. 364 - 366
反应条件
18-crown-6 ether Yield given;
参考文献
Mazurov, A. A.; Kabanov, V. M.; Andronati, S. A.
Doklady Chemistry, 1989 , vol. 306, # 1-3 p. 154 - 155
Dokl. Akad. Nauk SSSR Ser. Khim., 1989 , vol. 306, # 2 p. 364 - 366
反应条件
1: 39 percent / NaCl, LiClO4 / electrolysis 2: 87 percent / 98percent HCO2H / 2.5 h View Scheme
参考文献
Brungs; Danielmeier; Jakobi; Nothhelfer; Stahl; Zietlow; Steckhan
Journal de Chimie Physique et de Physico-Chimie Biologique, 1996 , vol. 93, # 4 p. 575 - 590
参考文献
Shvachkin, Yu. P.; Krivtsov, V. F.
J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 2 p. 466 - 467,410 - 411
