甲基1-{[(2-甲基-2-丙基)氧基]羰基}-L-脯氨酰甘氨酸酯合成路线 （共 14 条）
反应条件
1: 39 percent / NaCl, LiClO4 / electrolysis 2: 87 percent / 98percent HCO2H / 2.5 h 3: 90 percent / TiCl4 / CH2Cl2 / 1.) -65 deg C -> 0 deg C, 4.5 h, 2.) room temperature, 22 h 4: 62 percent / 6N HCl / 10 h / 90 °C View Scheme
参考文献
Kardassis, Georgios; Brungs, Peter; Steckhan, Eberhard
Tetrahedron, 1998 , vol. 54, # 14 p. 3471 - 3478
反应条件
1: lithium perchlorate; sodium bromide / Electrolysis 2: formic acid / 2-methyl-propan-1-ol; toluene / Reflux View Scheme
参考文献
Gorewoda, Tadeusz; Mazurkiewicz, Roman; Simka, Wojciech; Mloston, Grzegorz; Schroeder, Grzegorz; Kubicki, MacIej; Kuznik, Nikodem
Tetrahedron Asymmetry, 2011 , vol. 22, # 8 p. 823 - 833
参考文献
Shvachkin, Yu. P.; Krivtsov, V. F.
J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 2 p. 466 - 467,410 - 411
反应条件
1.1: HCl / ethyl acetate; H2O / 0.5 h
1.2: 86 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
2.1: 87 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
3.1: HCl / ethyl acetate; H2O / 0.5 h
3.2: 81 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
4.1: 80 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
5.1: HCl / ethyl acetate; H2O / 0.5 h
5.2: 80 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
6.1: 84 percent / Fmoc-Cl; NMM / tetrahydrofuran / 0.5 h / -15 °C
7.1: HCl / ethyl acetate; H2O / 0.5 h
7.2: 77 percent / Zn dust / tetrahydrofuran / 0.17 h / 20 °C
8.1: 50 percent / NaOH / methanol; H2O / 3 h / pH 8 - 9
View Scheme
参考文献
Tantry, Subramanyam J.; Ananda; Suresh Babu
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 5 p. 1028 - 1031
