1: dimethyl amine With acetic acid in water T=4.5 - 15°C; 2.66667 h; Inert atmosphere; 2: formaldehyd in water T=0 - 10°C; 0.333333 h; Inert atmosphere; 3: 6-Fluoro-1H-indole

1: formaldehyde diethyl acetal With formic acid in water T=80°C; 2 h; Reflux; 2: 6-Fluoro-1H-indole; dimethyl amine With acetic acid in water T=2 - 40°C; 3: With sodium hydroxide in water T=5 - 20°C; pH=> 14;

ethanol Erhitzen des Reaktionsprodukts mit wss. KOH;

tetrahydrofuran; acetic acid Hydrieren des erhaltenen <6-Fluor-indol-3-yl>-acetonitrils an Raney Nickel in methanol NH3;

in water; N,N-dimethyl-formamide T=100 - 105°C; 8 h;

tetrahydrofuran; acetic acid

1.1: N,N-dimethyl-formamide; water / 8 h / 100 - 105 °C 2.1: hydrogen; ammonia / water; methanol / 16 h / 60 °C / 1875.19 Torr 2.2: 0.25 h / Reflux 3.1: sodium hydroxide / toluene; tetrahydrofuran 3.2: 2.5 h / 60 °C 3.3: 2.5 h / 55 °C View Scheme