反式-2-(2-硝基乙烯基)噻吩合成路线 （共 19 条）
反应条件
piperidine; anhydrous iron chloride in toluene Henry Nitro Aldol Condensation; 2 h; Reflux;
参考文献
Jalal, Swapnadeep; Sarkar, Soumen; Bera, Krishnendu; Maiti, Sukhendu; Jana, Umasish
European Journal of Organic Chemistry, 2013 , # 22 p. 4823 - 4828
反应条件
H-Y zeolite in toluene 8 h; Heating;
参考文献
Anbazhagan; Kumaran; Sasidharan
Journal of Chemical Research - Part S, 1997 , # 9 p. 336 - 337
反应条件
hydrogenchloride; sodium hydroxide in methanol; water
参考文献
Shinogi and Co., Ltd.
Patent: US4839365 A1, 1989 ;
反应条件
tert.-butylnitrite; copper(l) chloride in acetonitrile T=80°C;
参考文献
Rokade, Balaji V.; Prabhu, Kandikere Ramaiah
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 39 p. 6713 - 6716
反应条件
1: triethylamine / 17 h 2: pyridine / 2 h / Ambient temperature 3: sodium carbonate / benzene / 5 h / Heating View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 61, # 11 p. 4029 - 4036
反应条件
copper(II) bis(trifluoromethanesulfonate); triethylamine in acetonitrile T=20°C; 6 h;
参考文献
Su, Weike; Ding, Kai; Chen, Zhiwei
Tetrahedron Letters, 2009 , vol. 50, # 6 p. 636 - 639
反应条件
1: N-methylmorpholine / toluene / 16 h / Ambient temperature 2: 64 percent / H2, AcOH / 5percent Pd/C / 5 h / 70 °C / 2280 Torr 3: 69 percent / diphenyl phosphorazidate, N-methylmorpholine / dimethylformamide / 16 h / Ambient temperature 4: 35 percent / 4 N aq. HCl / dioxane / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
1: N-methylmorpholine / toluene / 16 h / Ambient temperature 2: 64 percent / H2, AcOH / 5percent Pd/C / 5 h / 70 °C / 2280 Torr 3: 69 percent / diphenyl phosphorazidate, N-methylmorpholine / dimethylformamide / 16 h / Ambient temperature 4: 35 percent / 4 N aq. HCl / dioxane / 4 h / Ambient temperature 5: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 6: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature 7: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
反应条件
1: N-methylmorpholine / toluene / 16 h / Ambient temperature 2: 64 percent / H2, AcOH / 5percent Pd/C / 5 h / 70 °C / 2280 Torr 3: 69 percent / diphenyl phosphorazidate, N-methylmorpholine / dimethylformamide / 16 h / Ambient temperature 4: 35 percent / 4 N aq. HCl / dioxane / 4 h / Ambient temperature 5: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
反应条件
1: N-methylmorpholine / toluene / 16 h / Ambient temperature 2: 64 percent / H2, AcOH / 5percent Pd/C / 5 h / 70 °C / 2280 Torr 3: 69 percent / diphenyl phosphorazidate, N-methylmorpholine / dimethylformamide / 16 h / Ambient temperature 4: 35 percent / 4 N aq. HCl / dioxane / 4 h / Ambient temperature 5: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 6: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature 7: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature 8: 96 percent / 1 N aq. NaOH / 16 h / Ambient temperature View Scheme
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
