4-氯-3-三氟甲基苯甲醛合成路线 （共 7 条）
反应条件
sulfuryl dichloride; water; silica gel in chloroform T=0°C; 2 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 19 p. 3429 - 3447
反应条件
1: Mg / tetrahydrofuran / 5 h / Ambient temperature 2: SiO2, H2O, SO2Cl2 / CHCl3 / 2 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 19 p. 3429 - 3447
反应条件
(i) NaNO2, HCl, NaOAc, (ii) /BRN= 1697325/, CuSO4, Na2SO3, (iii) aq. HCl; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 14, p. 862 - 866
反应条件
sodium borohydride in methanol; chloroform
参考文献
Morton-Norwich Products, Inc.
Patent: US4063022 A1, 1977 ;
反应条件
potassium carbonate in water 0.5 h; Ambient temperature; Yield given. Title compound not separated from byproducts;
参考文献
Petit; Nallet; Guillard; Dreux; Chermat; Poncelet; Bulach; Simon
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 641 - 652
反应条件
methyl-magnesium chloride in tetrahydrofuran; diethyl ether T=-78 - -20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/101970 A1, 2003 ;
Location in patent: Page 10-11 ;
WO 03/101970 A1
反应条件
1: in tetrahydrofuran; diethyl ether T=-78°C; Inert atmosphere; 2: With ammonium chloride in tetrahydrofuran; diethyl ether
参考文献
PIERRE FABRE MEDICAMENT; PEREZ, Michel; LAMOTHE, Marie; JUNQUERO, Didier; RIVAL, Yves
Patent: WO2010/100139 A1, 2010 ;
Location in patent: Page/Page column 102 ;
WO 2010/100139 A1
