1: 95 percent / 1 M aq.K2CO3 / tetrahydrofuran / Ambient temperature 2: kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate View Scheme
1: 1.) 1,1'-carbonyldiimidazole / 1.) acetonitrile, RT, 20 min, 2.) acetonitrile, RT, 6 h 2: 69 percent / CrO3, pyridine / CH2Cl2 / 1 h / Ambient temperature 3: 76 percent / 5N HCl, 3-Angstroem molecular sieves, NaBH3CN / methanol / 72 h / Ambient temperature View Scheme
参考文献
Scopes, David I. C.; Hayes, Norman F.; Bays, David E.; Belton, David; Brain, John; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 490 - 501
