1: 95 percent / 1 M aq.K2CO3 / tetrahydrofuran / Ambient temperature 2: kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate 3: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, -70 deg C, 90 min, 2.) CH2Cl2, from -70 deg C to RT View Scheme
1.1: acetonitrile / 20 h / 25 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 25 °C
2.2: 20 h / 20 °C
3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 h / 25 °C
View Scheme
