反应条件
1: 90 percent / 1 M aq.K2CO3 / tetrahydrofuran / Ambient temperature
2: kinetic resolution through transesterification using acylase I from Aspergillus sp. and vinyl butyrate
3: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, -70 deg C, 90 min, 2.) CH2Cl2, from -70 deg C to RT
4: 1.) BuLi / 1.) hexane, THF, 0 deg C, 30 min, 2.) hexane, THF, from -70 deg C to RT overnight
5: H2 / 10percent Pd/C / methanol / 6 h / 2327.2 Torr
View Scheme
参考文献
Sanchez-Sancho, Francisco; Herradon, Bernardo
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1951 - 1965
