反应条件
1: 96 percent / tetrahydrofuran; diethyl ether / 1.5 h / Heating
2: 73 percent / 9-BBN, 6M NaOH, 30percent H2O2 / 1.5 h / 50 °C
3: 66 percent / chromium trioxide, 1.5M sulfuric acid / acetone / 4 h / 0 °C
4: thionyl chloride / 2.5 h / Ambient temperature
View Scheme
参考文献
Ghoneim, Ola M.; Legere, Jacqueline A.; Golbraikh, Alexander; Tropsha, Alexander; Booth, Raymond G.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 19 p. 6640 - 6658