1: With sodium t-butanolate; tri-tert-butyl phosphine; palladium diacetate in toluene T=42°C; 22 h; Inert atmosphere; 2: With acetic acid in water; toluene 0.166667 h;

sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0) in n-heptane; water; toluene

1: tert-butyl 4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: bromo-malonic acid ethyl ester-amide in N,N-dimethyl-formamide T=20 - 120°C; 7 h;

potassium carbonate