4-溴-3-氟-N-甲氧基-N-甲基苯胺合成路线 （共 6 条）
反应条件
1: 4-Bromo-3-fluorobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 2 h; 2: O,N-dimethyl-hydroxylamine hydrochloride With potassium carbonate in dichloromethane; water T=20°C; 2 h;
参考文献
INCYTE CORPORATION
Patent: US2008/39457 A1, 2008 ;
Location in patent: Page/Page column 40-41 ;
US 20080039457 A1
反应条件
benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
INCYTE CORPORATION; ZHUO, Jincong; METCALF, Brian
Patent: WO2008/64157 A1, 2008 ;
Location in patent: Page/Page column 42 ;
反应条件
triethylamine in dichloromethane; N,N-dimethyl-formamide T=0 - 20°C;
参考文献
INCYTE CORPORATION
Patent: US2011/212967 A1, 2011 ;
Location in patent: Page/Page column 7-8 ;
反应条件
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C;
参考文献
Chen, David; Franklin, Christopher L.; Guzzo, Peter R.; Lin, Linus S.; Lo, Michael M.C.; Nargund, Ravi P.; Sebhat, Iyassu K.
Patent: US2010/22598 A1, 2010 ;
Location in patent: Page/Page column 31 ;
反应条件
1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C 2: potassium carbonate / dichloromethane; water / 2 h / 20 °C View Scheme
参考文献
INCYTE CORPORATION
Patent: US2011/212967 A1, 2011 ;
反应条件
in tetrahydrofuran T=0°C; 1 h;
参考文献
INCYTE CORPORATION
Patent: US2008/39457 A1, 2008 ;
Location in patent: Page/Page column 41 ;
US 20080039457 A1
