5-(4-三氟甲基-苯基)-噻吩-2-甲醛合成路线 （共 3 条）
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in methanol; water; toluene T=80°C; 18 h;
参考文献
Kuo, Gee-Hong; Zhang, Yan; Shen, Lan; Lu, Songfeng; Demarest, Keith T.; Peiton, Patricia
Patent: US2007/244094 A1, 2007 ;
Location in patent: Page/Page column 29-30 ;
反应条件
1: 2-(4-trifluoromethylphenyl) thiophene With n-butyllithium in tetrahydrofuran; hexane T=-78 - -70°C; 1 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-70°C; 2 h;
参考文献
Tokyo Institute of Technology; Kuraray Co., Ltd.
Patent: EP2511278 A1, 2012 ;
Location in patent: Page/Page column 12 ;
反应条件
potassium acetate; palladium diacetate in N,N-dimethyl acetamide T=150°C; Heck reaction; 20 h; Inert atmosphere;
参考文献
Roger, Julien; Pozgan, Franc; Doucet, Henri
Green Chemistry, 2009 , vol. 11, # 3 p. 425 - 432
