4-氨基-4-甲基哌啶-1-甲酸叔丁酯合成路线 （共 8 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=25°C; 16 h;
参考文献
PURDUE PHARMA L.P.; SHIONOGI and CO., LTD.
Patent: WO2008/89201 A2, 2008 ;
Location in patent: Page/Page column 234-235 ;
WO 2008/089201 A2
反应条件
1: With hydrogen; acetic acid; palladium hydroxide on carbon in methanol T=20°C; P=2585.81 Torr; 2: With ammonia; water
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/119718 A1, 2008 ;
Location in patent: Page/Page column 45 ;
WO 2008/119718 A1
反应条件
water; potassium hydroxide in tetrahydrofuran T=20°C; 18 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2010/137305 A1, 2010 ;
Location in patent: Page/Page column 37 ;
反应条件
1: NMM / tetrahydrofuran / 1 h / -15 °C 2: aq. NaN3 / tetrahydrofuran / -15 - 20 °C 3: toluene / 1.5 h / 90 °C 4: aq. KOH / tetrahydrofuran / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 14 p. 3675 - 3678
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin; potassium hydroxide in water; acetonitrile T=1 - 23°C; Hofmann rearrangement; 1.5 h; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 13, # 6 p. 1145 - 1155
反应条件
1: LDA / tetrahydrofuran / -78 °C 2: LiOH / methanol / 20 °C 3: NMM / tetrahydrofuran / 1 h / -15 °C 4: aq. NaN3 / tetrahydrofuran / -15 - 20 °C 5: toluene / 1.5 h / 90 °C 6: aq. KOH / tetrahydrofuran / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 14 p. 3675 - 3678
反应条件
1: LiOH / methanol / 20 °C 2: NMM / tetrahydrofuran / 1 h / -15 °C 3: aq. NaN3 / tetrahydrofuran / -15 - 20 °C 4: toluene / 1.5 h / 90 °C 5: aq. KOH / tetrahydrofuran / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 14 p. 3675 - 3678
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile Heating;
参考文献
Feng, Dong-Zhi; Song, Yan-Li; Jiang, Xiao-Hua; Chen, Li; Long, Ya-Qiu
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 16 p. 2690 - 2697
