5-溴-4-氯-6-甲基嘧啶合成路线 （共 10 条）
反应条件
trichlorophosphate T=20°C; 3 h; Inert atmosphereReflux;
参考文献
Wang, Zhihan; Chi, Yushi; Harris, Anthony R.; Gray, David; Davoren, Jennifer E.
Synthesis, 2011 , # 10 art. no. M25011SS, p. 1529 - 1531
反应条件
1: N-bromosuccinmide / acetonitrile / 1 h / 20 °C / Inert atmosphere 2: trichlorophosphate / 3 h / 20 °C / Inert atmosphere; Reflux View Scheme
参考文献
Synthesis, , # 10 art. no. M25011SS, p. 1529 - 1531
反应条件
potassium phosphate; palladium diacetate; tris-(o-tolyl)phosphine in ethanol; water; toluene T=80°C; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Synthesis, , # 21 art. no. T60411SS, p. 3496 - 3506
反应条件
toluene-4-sulfonic acid hydrazide in chloroform 12 h; Heating;
参考文献
Yamanaka, Hiroshi; Sakamoto, Takao; Nishimura, Sumiko; Sagi, Mataichi
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 8 p. 3119 - 3126
反应条件
18-crown-6 ether in acetonitrile 16 h; Reflux;
参考文献
Wang, Zhihan; Chi, Yushi; Harris, Anthony R.; Gray, David; Davoren, Jennifer E.
Synthesis, 2011 , # 10 art. no. M25011SS, p. 1529 - 1531
反应条件
1: 51 percent / tosylhydrazine / CHCl3 / 12 h / Heating 2: 20 percent / MoO3, 30percent H2O2 / acetic acid / 16 h / 40 °C 3: 72 percent / Et3N / acetonitrile / 4 h / Ambient temperature View Scheme
参考文献
Yamanaka, Hiroshi; Sakamoto, Takao; Nishimura, Sumiko; Sagi, Mataichi
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 8 p. 3119 - 3126
反应条件
potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane
T=90°C; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Blachut, Dariusz; Szawkalo, Joanna; Czarnocki, Zbigniew
Synthesis, 2011 , # 21 art. no. T60411SS, p. 3496 - 3506
反应条件
potassium phosphate; palladium dichloride in ethanol; toluene
T=80°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Blachut, Dariusz; Szawkalo, Joanna; Czarnocki, Zbigniew
Synthesis, 2011 , # 21 art. no. T60411SS, p. 3496 - 3506
反应条件
in methanol
T=20°C; 1 h;
参考文献
INCYTE CORPORATION
Patent: WO2005/105814 A1, 2005 ;
Location in patent: Page/Page column 67-68 ;
WO 2005/105814 A1
反应条件
sodium methylate
T=20°C; 3 h; chemoselective reaction;
参考文献
Wang, Zhihan; Chi, Yushi; Harris, Anthony R.; Gray, David; Davoren, Jennifer E.
Synthesis, 2011 , # 10 art. no. M25011SS, p. 1529 - 1531
