2-氨基-4-三氟甲基噻唑-5-甲酸乙酯合成路线 （共 13 条）
反应条件
1: With sodium nitrite in water; hydrogen bromide T=0°C; 2: With copper bromide in water; hydrogen bromide T=0 - 20°C; 2.5 h;
参考文献
Boy, Kenneth M.; Wu, Yong-Jin; Guernon, Jason M.
Patent: US2004/147401 A1, 2004 ;
Location in patent: Page 32 ;
US 20040147401 A1
反应条件
1: 1) nitrosylsulfuric acid / 1) acetic acid, 30 min, 2) acetic acid, 15-20 deg C, 15 h 2: 56 percent / LiAlH4 / diethyl ether / 15 h / -10 °C View Scheme
参考文献
Tanaka, Kiyoshi; Nomura, Kazuto; Oda, Hitoshi; Yoshida, Shouhei; Mitsuhashi, Keiryo
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 907 - 911
反应条件
1.1: sodium nitrite / aq. HBr; H2O / 0 °C
1.2: 93 percent / copper bromide / aq. HBr; H2O / 2.5 h / 0 - 20 °C
2.1: 62 percent / 2,6-di-t-butyl-4-methylphenol / palladium tetrakistriphenylphosphine / toluene / 0.5 h / 120 °C
View Scheme
参考文献
Boy, Kenneth M.; Guernon, Jason M.
Tetrahedron Letters, 2005 , vol. 46, # 13 p. 2251 - 2252
