3-(4-氨基-7H-吡咯[2,3-d]-5-嘧啶)苯酚合成路线 （共 6 条）
反应条件
sodium ethanolate in ethanol T=80°C;
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
反应条件
1.1: NaN3; CH3N[(CH2)7CH3]3Cl / toluene / 55 °C 2.1: H2; HCl / Pt/C / methanol 3.1: Et3N / tetrahydrofuran / 20 °C 4.1: NaOEt / ethanol / 55 °C 5.1: 80 °C 5.2: NH3 / methanol / 20 °C 6.1: NaOEt / ethanol / 80 °C View Scheme
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
反应条件
1.1: H2; HCl / Pt/C / methanol 2.1: Et3N / tetrahydrofuran / 20 °C 3.1: NaOEt / ethanol / 55 °C 4.1: 80 °C 4.2: NH3 / methanol / 20 °C 5.1: NaOEt / ethanol / 80 °C View Scheme
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
反应条件
1.1: Et3N / tetrahydrofuran / 20 °C 2.1: NaOEt / ethanol / 55 °C 3.1: 80 °C 3.2: NH3 / methanol / 20 °C 4.1: NaOEt / ethanol / 80 °C View Scheme
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
反应条件
1.1: NaOEt / ethanol / 55 °C 2.1: 80 °C 2.2: NH3 / methanol / 20 °C 3.1: NaOEt / ethanol / 80 °C View Scheme
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
反应条件
1.1: 80 °C 1.2: NH3 / methanol / 20 °C 2.1: NaOEt / ethanol / 80 °C View Scheme
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
