4-羟基-6-甲基-2-(甲基硫代)嘧啶-5-羧酸乙酯合成路线 （共 5 条）
反应条件
N-bromosuccinmide; potassium carbonate; dibenzoyl peroxide in 1,4-dioxane T=90°C; 3 h;
参考文献
Pharmacia Italia S.p.A.
Patent: US2004/9993 A1, 2004 ;
Location in patent: Page/Page column 28-30 ;
反应条件
1: in dichloromethane T=20°C; 4 h; 2: With triethylamine
参考文献
Landreau; Deniaud; Reliquet; Meslin
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 1 p. 93 - 98
反应条件
1: in dichloromethane T=20°C; 4 h; 2: With triethylamine in dichloromethane T=0°C;
参考文献
EXELIXIS, INC.
Patent: WO2008/124161 A1, 2008 ;
Location in patent: Page/Page column 263-264 ;
WO 2008/124161 A1
反应条件
1: With TEA in ethanol 3 h; Heating; 2: With N-bromosuccinmide; potassium carbonate; dibenzoyl peroxide in 1,4-dioxane T=90°C; 3 h;
参考文献
Tetrahedron Letters, , vol. 46, # 50 p. 8749 - 8752
反应条件
1: With N-ethyl-N,N-diisopropylamine; trichlorophosphate T=80 - 90°C; 2 h; 2: With sodium hydrogencarbonate in dichloromethane; water Cooling with ice;
参考文献
GENOSCO; OSCOTEC INC.; KIM, Hong, Woo; KOH, Jong, Sung; LEE, Jaekyoo; SONG, Ho-Juhn; KIM, Youngsam; LEE, Hee, Kyu; CHOI, Jang-Sik; LIM, Sun-Hee; CHANG, Sunhwa
Patent: WO2011/53861 A1, 2011 ;
Location in patent: Page/Page column 46 ;
WO 2011/053861 A1
