1-甲基-3-三氟甲基吡唑-5-硼酸合成路线 (共 3 条)
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 3 h; 2: With hydrogenchloride in tetrahydrofuran; hexane pH=6;
参考文献
WO2005/12254 A1, ;
Page/Page column 135-136 ;
WO 2005/012254 A1
反应条件
1: 1-methyl-3-trifluoromethylpyrazol With n-butyllithium in tetrahydrofuran; hexanes; hexane T=-78°C; 1 h; 2: boric acid trimethyl ester in tetrahydrofuran; hexanes T=-78 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; hexanes; water T=20°C; 1.5 h;
参考文献
WO2012/7868 A2, ;
Page/Page column 75 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane T=-75 - 20°C;
参考文献
WO2009/43883 A1, ;
Page/Page column 46-47 ;
WO 2009/043883 A1