6-甲基-2,3,4,9-四氢-1H-咔唑-1-酮合成路线 （共 18 条）
反应条件
potassium hydride; sodium hydride in benzene 2 h; Heating;
参考文献
Journal of Chemical Research, , # 12 p. 699 - 704
反应条件
1: With sodium hydride in benzene T=20°C; 30 h; 2: With sodium acetate; acetic anhydride T=170°C; 10 h;
参考文献
Danish, I. Antony; Rajendra Prasad
Organic Preparations and Procedures International, 2004 , vol. 36, # 4 p. 371 - 374
反应条件
1: 59 percent / methanol / 1 h / Heating 2: 90 percent / sodium borohydride / methanol / 2 h / Ambient temperature View Scheme
参考文献
Filitis, L. N.; Akalaeva, T. V.; Amel'kin, O. Yu.; Bokanov, A. I.; Ivanov, P. Yu.; Shvedov, V. I.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 10 p. 780 - 785
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 10 p. 1217 - 1222
反应条件
1: 88 percent / p-toluenesulfonic acid / toluene / 5 h / Heating 2: NaBH4 / ethanol / 1 h / 20 °C View Scheme
参考文献
Akalaeva, T. V.; Bokanov, A. I.; Ivanov, P. Yu.; Nikolaeva, I. S.; Pushkina, T. V.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 3 p. 231 - 234
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 3 p. 299 - 302
反应条件
1: 86 percent / xylene / 3 h / Heating 2: NaBH4 / ethanol / 1 h / 20 °C View Scheme
参考文献
Bokanov, A. I.; Ivanov, P. Yu.; Akalaeva, T. V.; Bogdanova, G. A.; Shvedov, V. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 12 p. 1311 - 1315
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 12 p. 1632 - 1635
反应条件
1: 93 percent / toluene / 7 h / Heating 2: 80.5 percent / NaBH4 / ethanol / 1 h / 20 °C View Scheme
参考文献
Filitis, L. N.; Akalaeva, T. V.; Amel'kin, O. Yu.; Bokanov, A. I.; Ivanov, P. Yu.; Shvedov, V. I.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 10 p. 780 - 785
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 10 p. 1217 - 1222
反应条件
1: 97.4 percent / xylene / 3 h / Heating
2: 81.7 percent / SOCl2 / dimethylformamide; benzene / 2 h / 50 - 55 °C
3: NaBH4 / ethanol / 0.5 h / 0 - 5 °C
4: 68.4 percent / 50percent aq. NaOH / tetrabutylammonium bromide / benzene / 5 h / Ambient temperature
View Scheme
参考文献
Ivanov, P. Yu.; Alekseeva, L. M.; Bokanov, A. I.; Shvedov, V. I.; Sheinker, Yu. N.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 1 p. 62 - 65
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 1 p. 71 - 75
反应条件
potassium hydroxide; sodium hydroxide
T=230°C; 1 h;
参考文献
Bhattacharyya, P.; Jash, S. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 1056
