3-(4-氟苯基)戊二酸合成路线 （共 15 条）
反应条件
1: With sodium hydroxide in ethanol; water 1 h; Reflux; 2: With hydrogenchloride in ethanol; water pH=1;
参考文献
Rios-Lombardia, Nicolas; Gotor-Fernandez, Vicente; Gotor, Vicente
Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 811 - 819
参考文献
Dey,A.S.; Joullie,M.M.
Journal of Organic Chemistry, 1965 , vol. 30, p. 3237 - 3239
反应条件
1.1: 99 percent / thionyl chloride / 18 h / 20 °C 2.1: Na; MeOH / 0.5 h 2.2: 67 percent / methanol / 20 h / Heating 3.1: aq. NaOH / 20 h / Heating 4.1: 15.5 g / aq. HCl / 20 h / Heating View Scheme
参考文献
Liu, Lee Tai; Hong, Pao-Chiung; Huang, Hsiang-Ling; Chen, Shyh-Fong; Wang, Chia-Lin Jeff; Wen, Yuh-Sheng
Tetrahedron Asymmetry, 2001 , vol. 12, # 3 p. 419 - 426
反应条件
1.1: Na; MeOH / 0.5 h 1.2: 67 percent / methanol / 20 h / Heating 2.1: aq. NaOH / 20 h / Heating 3.1: 15.5 g / aq. HCl / 20 h / Heating View Scheme
参考文献
Liu, Lee Tai; Hong, Pao-Chiung; Huang, Hsiang-Ling; Chen, Shyh-Fong; Wang, Chia-Lin Jeff; Wen, Yuh-Sheng
Tetrahedron Asymmetry, 2001 , vol. 12, # 3 p. 419 - 426
反应条件
1: 1.) urea, 2.) ethanol / 1.) 160 deg C - 180 deg C, 2 h, 2.) reflux, 10 min 2: 95 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Perregaard; Moltzen; Meier; Sanchez
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1998 - 2008
