2-羟基-4-三氟甲基苯甲酸甲酯合成路线 （共 3 条）
反应条件
hydrogenchloride; sulfuric acid in water
T=80°C;
参考文献
ENVIVO PHARMACEUTICALS, INC.; METHYLGENE INC.
Patent: WO2009/137499 A1, 2009 ;
Location in patent: Page/Page column 81 ;
WO 2009/137499 A1
反应条件
lithium carbonate in N,N-dimethyl-formamide
T=60°C; 2 h; Inert atmosphere;
参考文献
Hammann, Jeffrey M.; Unzner, Teresa A.; Magauer, Thomas
Chemistry - A European Journal, 2014 , vol. 20, # 22 p. 6733 - 6738
反应条件
ammonium hydroxide; aluminium
参考文献
Hauptschein et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 4476
