4-氟-4'-甲氧基二苯甲酮合成路线 （共 26 条）
反应条件
in dimethyl sulfoxide T=70 - 80°C;
参考文献
Ridd, John H.; Yousaf, Taher I.; Rose, John B.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1988 , p. 1729 - 1734
反应条件
1: 1.) conc. aq. HCl, NaNO2 / 1.) H2O, 20 min, 2.) H2O, RT, 0.5 h 2: 37 percent / 40percent aq. HF / benzene / 1.) RT, 0.5 h, 2.) 50 deg C, 10 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1504 - 1511
反应条件
1: 6N aq. HCl / 1 h / Heating 2: 1.) conc. aq. HCl, NaNO2 / 1.) H2O, 20 min, 2.) H2O, RT, 0.5 h 3: 37 percent / 40percent aq. HF / benzene / 1.) RT, 0.5 h, 2.) 50 deg C, 10 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1504 - 1511
反应条件
1: 72 percent / AlCl3 / CS2 / 1 h / Ambient temperature 2: 62 percent / Na2S2O4*H2O / ethanol / Heating 3: 1.) conc. aq. HCl, NaNO2 / 1.) H2O, 20 min, 2.) H2O, RT, 0.5 h 4: 37 percent / 40percent aq. HF / benzene / 1.) RT, 0.5 h, 2.) 50 deg C, 10 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1504 - 1511
反应条件
1: 72 percent / AlCl3 / CS2 / 1 h / Ambient temperature 2: 62 percent / Na2S2O4*H2O / ethanol / Heating 3: 1.) conc. aq. HCl, NaNO2 / 1.) H2O, 20 min, 2.) H2O, RT, 0.5 h 4: 37 percent / 40percent aq. HF / benzene / 1.) RT, 0.5 h, 2.) 50 deg C, 10 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1504 - 1511
参考文献
Journal of the American Chemical Society, , vol. 91, p. 3037 - 3044
反应条件
1: With trifluoroacetic anhydride T=80°C; 2: With boron trifluoride diethyl etherate T=80°C; Friedel-Crafts reaction; Title compound not separated from byproducts;
参考文献
Synlett, , # 7 p. 1063 - 1066
反应条件
1: KOH / methanol; H2O 2: 52 percent / dimethylsulfoxide / 70 - 80 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1729 - 1734
反应条件
1: 81 percent / KOH / H2O; dimethylsulfoxide / 18 h / 60 °C 2: KOH / methanol; H2O 3: 52 percent / dimethylsulfoxide / 70 - 80 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1729 - 1734
反应条件
aluminium trichloride
参考文献
Journal of the Chemical Society, , p. 1854,1855
