4,4'-二氟二苯甲酮合成路线 （共 115 条）
反应条件
1: 85 percent / diethyl ether; tetrahydrofuran / 5 h / Heating
2: 93 percent / H2 / HRh(CO)(PPh3)3 / toluene / 5 h / 60 °C / 76000 Torr
3: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C
4: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating
5: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C
View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 1.) Mg, 3.) CF3COOH
2: 1.) 2,2,2-trichloroethyl chloroformate, K2CO3, 2.) Zn, 1M aq. NH4Cl / 1.) 1,1,2-trichloroethane, reflux, 11 h, 2.) THF, RT, 24 h
View Scheme
参考文献
Suzuki, Tsuneji; Fukazawa, Nobuyuki; San-nohe, Kunio; Sato, Wakao; Yano, Osamu; Tsuruo, Takashi
Journal of Medicinal Chemistry, 1997 , vol. 40, # 13 p. 2047 - 2052
反应条件
1: 81 percent / KOH / H2O; dimethylsulfoxide / 18 h / 60 °C
2: KOH / methanol; H2O
3: 52 percent / dimethylsulfoxide / 70 - 80 °C
4: KOH / H2O; dimethylsulfoxide / 18 h / 60 °C
View Scheme
参考文献
Ridd, John H.; Yousaf, Taher I.; Rose, John B.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1988 , p. 1729 - 1734
反应条件
1: diethyl ether / 1 h
2: p-TsOH / benzene / Heating
View Scheme
参考文献
Kao, Hsien-Ming; Grey, Clare P.; Pitchumani, Kasi; Lakshminarasimhan; Ramamurthy
Journal of Physical Chemistry A, 1998 , vol. 102, # 28 p. 5627 - 5638
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran
T=0°C; 0.5 h;
2: 1,1-di(p-fluorophenyl)-ketone in tetrahydrofuran
T=0 - 20°C; 16 h;
参考文献
Liwosz, Timothy W.; Chemler, Sherry R.
Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12771 - 12777
反应条件
in tetrahydrofuran
1 h;
参考文献
Subramanyam; Mallamo; Dority Jr.; Earley; Kumar; Aimone; Ault; Miller; Luttinger; DeHaven-Hudkins
Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 21 - 27
参考文献
Coates; Sutton
Journal of the Chemical Society, 1942 , p. 567,568
反应条件
in water; N,N-dimethyl-formamide
T=0 - 20°C; 3.08333 h;
参考文献
Dekan, Zoltan; Mobli, Mehdi; Pennington, Michael W.; Fung, Eileen; Nemeth, Elizabeta; Alewood, Paul F.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 11 p. 2931 - 2934
Angew. Chem., 2014 , vol. 126, # 11 p. 2975 - 2978,4
反应条件
1: 85 percent / K2CO3 / dimethylsulfoxide / 60 deg C, 1 week; 80 deg C, 4 h
2: various solvent(s) / 200 °C
View Scheme
参考文献
Ridd, John H.; Yousaf, Taher I.; Rose, John B.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1988 , p. 1729 - 1734
反应条件
1: 1.) magnesium / 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 2.) reflux, 2.5 h
2: thionyl chloride / Heating
View Scheme
参考文献
Bartroli; Alguero; Boncompte; Forn
Arzneimittel-Forschung/Drug Research, 1992 , vol. 42, # 6 p. 832 - 835
