4,4'-二氟二苯甲酮合成路线 （共 115 条）
反应条件
hydrogenchloride in tert.-butyl-methyl ether
参考文献
Mobele, Bingidimi I.; Venkatraman, Sripathy; McNaughton-Smith, Grant; Gibb, Cameron; Ulysse, Luckner G.; Lindmark, Carl A.; Shaw, Stephen; Marron, Brian; Spear, Kerry; Suto, Mark J.
Organic Process Research and Development, 2012 , vol. 16, # 8 p. 1385 - 1392
反应条件
1: in various solvent(s)
3 h; Heating;
2: With hydrogenchloride
Further stages.;
参考文献
McNaughton-Smith, Grant A.; Burns, J. Ford; Stocker, Jonathan W.; Rigdon, Gregory C.; Creech, Christopher; Arlington, Susan; Shelton, Tara; De Franceschi, Lucia
Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 976 - 982
反应条件
1: (i) Mg, EtBr, (ii) /BRN= 516231/
2: aq. HCl, AcOH
3: (i) MeI, (ii) aq. NaOH
View Scheme
参考文献
Holm,T.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 2437 - 2443
反应条件
1: NaH
2: aq. KOH
3: aq. HBr, AcOH
View Scheme
参考文献
Sindelar; Rajsner; Cervena; et al.
1973 , vol. 38, # 12 p. 3879 - 3901
反应条件
1: n-BuLi, HMDS / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) -78 deg C to r.t., 30 min
2: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -60 - 0 °C
View Scheme
参考文献
Mouries, Virginie; Waschbuesch, Rachel; Carran, John; Savignac, Philippe
Synthesis, 1998 , # 3 p. 271 - 274
