4,4'-二氟二苯甲酮合成路线 （共 115 条）
反应条件
methanol; sodium tetrahydroborate T=0 - 20°C;
参考文献
Shivprakash; Reddy, G. Chandrasekara
Synthetic Communications, 2014 , vol. 44, # 5 p. 600 - 609
反应条件
1: methanol With N-benzyl-trimethylammonium hydroxide 0.166667 h; Neat (no solvent); 2: 1,1-di(p-fluorophenyl)-ketone T=20°C; 0.166667 h; Neat (no solvent);
参考文献
Meshram; Goud, P. Ramesh; Reddy, B. Chennakesava; Kumar, D. Aravind
Synthetic Communications, 2010 , vol. 40, # 14 p. 2122 - 2129
反应条件
1: 81 percent / KOH / H2O; dimethylsulfoxide / 18 h / 60 °C 2: KOH / methanol; H2O 3: 52 percent / dimethylsulfoxide / 70 - 80 °C View Scheme
参考文献
Ridd, John H.; Yousaf, Taher I.; Rose, John B.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1988 , p. 1729 - 1734
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6248766 B1, 2001 ;
反应条件
1-amino-3,5-dimethyl-adamantane; potassium carbonate 1) toluene, reflux, 3 h, 2) 140-150 deg C, 5 h; Yield given. Multistep reaction;
参考文献
Rusanov; Matvelashvili; Kazakova; Kesktov; Mikitaev
Russian Chemical Bulletin, 1996 , vol. 45, # 3 p. 633 - 636
反应条件
1.1: toluene; tetrahydrofuran / 20 - 50 °C / |Large scale 2.1: indium(III) chloride / toluene / 0.5 h / 20 °C / |Large scale 2.2: 2.5 h / 20 - 40 °C / |Large scale 3.1: potassium hydroxide / 1,1-dimethylpropan-1-ol / 10.5 h / 85 - 95 °C / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 8 p. 1385 - 1392
反应条件
1.1: toluene; tetrahydrofuran / 20 - 50 °C / |Large scale 2.1: indium(III) chloride / toluene / 0.5 h / 20 °C / |Large scale 2.2: 2.5 h / 20 - 40 °C / |Large scale 3.1: potassium hydroxide / 1,1-dimethylpropan-1-ol / 12 h / 100 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 8 p. 1385 - 1392
反应条件
1.1: toluene; tetrahydrofuran / 20 - 50 °C / |Large scale 2.1: indium(III) chloride / toluene / 0.5 h / 20 °C / |Large scale 2.2: 2.5 h / 20 - 40 °C / |Large scale 3.1: sulfuric acid; acetic acid / 125 - 130 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 8 p. 1385 - 1392
反应条件
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 0 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C 3: acetonitrile / Reflux View Scheme
参考文献
Shivprakash; Reddy, G. Chandrasekara
Synthetic Communications, 2014 , vol. 44, # 5 p. 600 - 609
反应条件
potassium tert-butylate in tetrahydrofuran T=25°C; 24 h;
参考文献
Billard, Thierry; Langlois, Bernard R.; Blond, Gaelle
European Journal of Organic Chemistry, 2001 , # 8 p. 1467 - 1471
