4,4'-二氟二苯甲酮合成路线 （共 115 条）
反应条件
1: With n-butyllithium in tetrahydrofuran 2: With potassium hydroxide in methanol
参考文献
Manuel Oliveira; Salvador, Maria A.; Vermeersch, Gaston; Berthet, Jerome; Delbaere, Stephanie
Molecular Crystals and Liquid Crystals, 2005 , vol. 431, p. 173/[473]-185/[485]
反应条件
in tetrahydrofuran T=20°C; 1 - 10 h;
参考文献
Mothe, Srinivasa Reddy; Lauw, Sherman Jun Liang; Kothandaraman, Prasath; Chan, Philip Wai Hong
Journal of Organic Chemistry, 2012 , vol. 77, # 16 p. 6937 - 6947
反应条件
1: zinc 2: aqueous formic acid View Scheme
参考文献
Voegtli; Laeuger
Helvetica Chimica Acta, 1955 , vol. 38, p. 46,63
反应条件
potassium carbonate in dimethyl sulfoxide 60 deg C, 1 week; 80 deg C, 4 h;
参考文献
Ridd, John H.; Yousaf, Taher I.; Rose, John B.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1988 , p. 1729 - 1734
反应条件
palladium diacetate; potassium carbonate; trifluoroacetic acid; silver(l) oxide T=140°C; Nazarov Cyclization; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Li, Hu; Zhu, Ru-Yi; Shi, Wen-Juan; He, Ke-Han; Shi, Zhang-Jie
Organic Letters, 2012 , vol. 14, # 18 p. 4850 - 4853,4
参考文献
Gabbutt, Christopher D.; Heron, B. Mark; McCreary, Janice M.; Thomas, David A.
Journal of Chemical Research - Part S, 2002 , # 2 p. 69 - 71
反应条件
1: 85 percent / diethyl ether; tetrahydrofuran / 5 h / Heating 2: 93 percent / H2 / HRh(CO)(PPh3)3 / toluene / 5 h / 60 °C / 76000 Torr 3: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C 4: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating 5: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C 6: 75 percent / Na2CO3; KI / toluene / Heating View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
potassium hydroxide in water; dimethyl sulfoxide T=60°C; 18 h;
参考文献
Ridd, John H.; Yousaf, Taher I.; Rose, John B.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1988 , p. 1729 - 1734
反应条件
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 0 °C 2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C View Scheme
参考文献
Shivprakash; Reddy, G. Chandrasekara
Synthetic Communications, 2014 , vol. 44, # 5 p. 600 - 609
反应条件
1: 91 percent / tetrahydrofuran / Heating 2: 99 percent / [Rh(cod)Cl]2 / dioxane / 65 h / 120 °C / 37503 Torr 3: 100 percent / HCl / ethanol / 4 h / Heating 4: 98 percent / H2 / Pd/C / ethanol / 72 h / 20 °C / 1125.09 Torr View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
