S-6-(叔丁氧基羰基)-5,6-二氢-6H-[1,4]二氮杂革并[6,7,1-hi]吲哚合成路线 （共 5 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=0°C;
参考文献
Al-awar, Rima S.; Ray, James E.; Hecker, Kyle A.; Joseph, Sajan; Huang, Jianping; Shih, Chuan; Brooks, Harold B.; Spencer, Charles D.; Watkins, Scott A.; Schultz, Richard M.; Considine, Eileen L.; Faul, Margaret M.; Sullivan, Kevin A.; Kolis, Stanley P.; Carr, Michael A.; Zhang, Faming
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3925 - 3928
反应条件
1: H2 / Pd/c / methanol / 20 °C / 760 Torr 2: aq. K2CO3 / tetrahydrofuran / 0 °C 3: Et3N / tetrahydrofuran / 2 h / 0 °C 4: NaH / dimethylformamide / 0 °C View Scheme
参考文献
Gunosewoyo, Hendra; Midzak, Andrew; Gaisina, Irina N.; Sabath, Emily V.; Fedolak, Allison; Hanania, Taleen; Brunner, Dani; Papadopoulos, Vassilios; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5115 - 5129
反应条件
1: aq. K2CO3 / tetrahydrofuran / 0 °C 2: Et3N / tetrahydrofuran / 2 h / 0 °C 3: NaH / dimethylformamide / 0 °C View Scheme
参考文献
Al-awar, Rima S.; Ray, James E.; Hecker, Kyle A.; Joseph, Sajan; Huang, Jianping; Shih, Chuan; Brooks, Harold B.; Spencer, Charles D.; Watkins, Scott A.; Schultz, Richard M.; Considine, Eileen L.; Faul, Margaret M.; Sullivan, Kevin A.; Kolis, Stanley P.; Carr, Michael A.; Zhang, Faming
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3925 - 3928
反应条件
1: aq. K2CO3 / tetrahydrofuran / 0 °C 2: Et3N / tetrahydrofuran / 2 h / 0 °C 3: NaH / dimethylformamide / 0 °C View Scheme
参考文献
Al-awar, Rima S.; Ray, James E.; Hecker, Kyle A.; Joseph, Sajan; Huang, Jianping; Shih, Chuan; Brooks, Harold B.; Spencer, Charles D.; Watkins, Scott A.; Schultz, Richard M.; Considine, Eileen L.; Faul, Margaret M.; Sullivan, Kevin A.; Kolis, Stanley P.; Carr, Michael A.; Zhang, Faming
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3925 - 3928
反应条件
1: Et3N / tetrahydrofuran / 2 h / 0 °C 2: NaH / dimethylformamide / 0 °C View Scheme
参考文献
Al-awar, Rima S.; Ray, James E.; Hecker, Kyle A.; Joseph, Sajan; Huang, Jianping; Shih, Chuan; Brooks, Harold B.; Spencer, Charles D.; Watkins, Scott A.; Schultz, Richard M.; Considine, Eileen L.; Faul, Margaret M.; Sullivan, Kevin A.; Kolis, Stanley P.; Carr, Michael A.; Zhang, Faming
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3925 - 3928
