甲基7-(5-氧代-1-环戊烯-1-基)庚酸酯合成路线 （共 105 条）
反应条件
(i) HgSO4, H2SO4, AcOH, (ii) aq. NaOH, (iii) (esterification); Multistep reaction;
参考文献
Mamdapur,V.R. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1979 , vol. 17, p. 269 - 271
反应条件
1: 9.62 g / NaBH4 / methanol / 2 h / Ambient temperature
2: 9.8 g / pyridine
3: 7.8 g / NaOH/85percent aq. MeOH / 2.5 h / Heating
4: 6.2 g / Jones' reagent / acetone / 0.5 h / 0 - 5 °C
5: 0.18 g / diethyl ether
View Scheme
参考文献
Thakur, S. B.; Jadhav, K. S.; Bhattacharyya, S. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 675 - 683
反应条件
N-bromosuccinmide; silver perchlorate in tetrachloromethane; ethyl acetate
参考文献
Syntex (U.S.A.) Inc.
Patent: US4046801 A1, 1977 ;
反应条件
1: 43 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 2.5 h / Heating
2: 92 percent / silver perchlorate / H2O; acetone / 1 h
View Scheme
参考文献
Thakur, S. B.; Jadhav, K. S.; Bhattacharyya, S. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 675 - 683
反应条件
1: 100 percent / N-bromosuccinimide, 2,2-azadiisobutyronitrile / CCl4 / 5 h / Heating
2: 62 percent / H2O / dioxane / 2.5 h / Heating
3: 72 percent / conc. HCl / 4 h / Ambient temperature
View Scheme
参考文献
Thakur, S. B.; Jadhav, K. S.; Bhattacharyya, S. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 675 - 683
