甲基7-(5-氧代-1-环戊烯-1-基)庚酸酯合成路线 （共 105 条）
反应条件
1: Acidic aqueous solution;
2: esterification;
参考文献
PHARMAGENE LABORATORIES LIMITED
Patent: WO2005/61449 A1, 2005 ;
Location in patent: Page/Page column 47 ;
反应条件
1: 89 percent / ZnBr2 / CH2Cl2 / 2 h / Ambient temperature
2: 1.) MCPBA / 1.) 0 deg C, 0.5 h, 2.) toluene, 100 deg C, 4 h
3: 62 percent / HCl / methanol; H2O / 8 h / Heating
View Scheme
参考文献
Kaji, Aritsune
Phosphorus and Sulfur and the Related Elements, 1985 , vol. 23, p. 211 - 222
反应条件
1: 89 percent / ZnBr2 / CH2Cl2 / 2 h / Ambient temperature
2: 1.) MCPBA / 1.) 0 deg C, 0.5 h, 2.) toluene, 100 deg C, 4 h
3: 62 percent / HCl / methanol; H2O / 8 h / Heating
View Scheme
参考文献
Kaji, Aritsune
Phosphorus and Sulfur and the Related Elements, 1985 , vol. 23, p. 211 - 222
反应条件
1: 1.) MCPBA / 1.) 0 deg C, 0.5 h, 2.) toluene, 100 deg C, 4 h
2: 62 percent / HCl / methanol; H2O / 8 h / Heating
View Scheme
参考文献
Kaji, Aritsune
Phosphorus and Sulfur and the Related Elements, 1985 , vol. 23, p. 211 - 222
反应条件
1: 71 percent / boron trifluoride etherate, p-toluenesulfonic acid / acetone; H2O / Ambient temperature
2: 72 percent / sodium methoxide / methanol
View Scheme
参考文献
Rosini, Goffredo; Ballini, Roberto; Petrini, Marino; Sorrenti, Pietro
Tetrahedron, 1984 , vol. 40, # 19 p. 3809 - 3814
反应条件
1: 56 percent
2: p-toluenesulfonic acid / Heating
3: 1) CaCO3, Br2, 2) Li2CO3, / 1) CCl4, water, 0-5 deg C, 30 min, 2) DMF, 30 min, reflux
4: 95.8 percent / pyridine; ethanol / 22 h / Ambient temperature
5: 2N HCl / acetone / 5 h / Heating
6: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 85 percent / pyridine; ethanol / 22 h / Ambient temperature
2: 80 percent / KOH / methanol; H2O / 18 h / Heating
3: 86.2 percent / triethylamine / CH2Cl2 / 0.5 h / cooling
4: 1) 57percent NaH / 1) 1h, DME; 2) DME, 16h, reflux
5: KOH / methanol; H2O / 18 h / Heating
6: various solvent(s) / Heating
7: 2N HCl / acetone / 5 h / Heating
8: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 85.9 percent / 25percent (i-Bu)2AlH / benzene; hexane / 1.5 h / 0 - 5 °C / 1) 0-5 deg C, 1.5h, 2) 15 min
2: 86.2 percent / triethylamine / CH2Cl2 / 0.5 h / cooling
3: 1) 57percent NaH / 1) 1h, DME; 2) DME, 16h, reflux
4: KOH / methanol; H2O / 18 h / Heating
5: various solvent(s) / Heating
6: 2N HCl / acetone / 5 h / Heating
7: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: KOH / methanol; H2O / 18 h / Heating
2: various solvent(s) / Heating
3: 2N HCl / acetone / 5 h / Heating
4: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 89 percent / p-toluenesulfonic acid / 8 h / Heating
2: CaCO3, Br2, sodium thiosulfate, LiBr, Li2CO3, p-toluenesulfonic acid
3: 84.1 percent / pyridine; ethanol / 22 h / Ambient temperature
4: 85.9 percent / 25percent (i-Bu)2AlH / benzene; hexane / 1.5 h / 0 - 5 °C / 1) 0-5 deg C, 1.5h, 2) 15 min
5: 86.2 percent / triethylamine / CH2Cl2 / 0.5 h / cooling
6: 1) 57percent NaH / 1) 1h, DME; 2) DME, 16h, reflux
7: KOH / methanol; H2O / 18 h / Heating
8: various solvent(s) / Heating
9: 2N HCl / acetone / 5 h / Heating
10: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
