甲基7-(5-氧代-1-环戊烯-1-基)庚酸酯合成路线 （共 105 条）
反应条件
1: 2N HCl / acetone / 5 h / Heating
2: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 95.8 percent / pyridine; ethanol / 22 h / Ambient temperature
2: 2N HCl / acetone / 5 h / Heating
3: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 2N HCl / acetone / 5 h / Heating
2: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: CaCO3, Br2, sodium thiosulfate, LiBr, Li2CO3, p-toluenesulfonic acid
2: 84.1 percent / pyridine; ethanol / 22 h / Ambient temperature
3: 85.9 percent / 25percent (i-Bu)2AlH / benzene; hexane / 1.5 h / 0 - 5 °C / 1) 0-5 deg C, 1.5h, 2) 15 min
4: 86.2 percent / triethylamine / CH2Cl2 / 0.5 h / cooling
5: 1) 57percent NaH / 1) 1h, DME; 2) DME, 16h, reflux
6: KOH / methanol; H2O / 18 h / Heating
7: various solvent(s) / Heating
8: 2N HCl / acetone / 5 h / Heating
9: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 1) 57percent NaH / 1) 1h, DME; 2) DME, 16h, reflux
2: KOH / methanol; H2O / 18 h / Heating
3: various solvent(s) / Heating
4: 2N HCl / acetone / 5 h / Heating
5: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: various solvent(s) / Heating
2: 2N HCl / acetone / 5 h / Heating
3: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 86.2 percent / triethylamine / CH2Cl2 / 0.5 h / cooling
2: 1) 57percent NaH / 1) 1h, DME; 2) DME, 16h, reflux
3: KOH / methanol; H2O / 18 h / Heating
4: various solvent(s) / Heating
5: 2N HCl / acetone / 5 h / Heating
6: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 80 percent / KOH / methanol; H2O / 18 h / Heating
2: 86.2 percent / triethylamine / CH2Cl2 / 0.5 h / cooling
3: 1) 57percent NaH / 1) 1h, DME; 2) DME, 16h, reflux
4: KOH / methanol; H2O / 18 h / Heating
5: various solvent(s) / Heating
6: 2N HCl / acetone / 5 h / Heating
7: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 74 percent / p-toluenesulfonic acid / 18 h / Heating
2: 89 percent / p-toluenesulfonic acid / 8 h / Heating
3: CaCO3, Br2, sodium thiosulfate, LiBr, Li2CO3, p-toluenesulfonic acid
4: 84.1 percent / pyridine; ethanol / 22 h / Ambient temperature
5: 85.9 percent / 25percent (i-Bu)2AlH / benzene; hexane / 1.5 h / 0 - 5 °C / 1) 0-5 deg C, 1.5h, 2) 15 min
6: 86.2 percent / triethylamine / CH2Cl2 / 0.5 h / cooling
7: 1) 57percent NaH / 1) 1h, DME; 2) DME, 16h, reflux
8: KOH / methanol; H2O / 18 h / Heating
9: various solvent(s) / Heating
10: 2N HCl / acetone / 5 h / Heating
11: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: p-toluenesulfonic acid / Heating
2: 1) CaCO3, Br2, 2) Li2CO3, / 1) CCl4, water, 0-5 deg C, 30 min, 2) DMF, 30 min, reflux
3: 95.8 percent / pyridine; ethanol / 22 h / Ambient temperature
4: 2N HCl / acetone / 5 h / Heating
5: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
