甲基7-(5-氧代-1-环戊烯-1-基)庚酸酯合成路线 （共 105 条）
反应条件
silver perchlorate in benzene
参考文献
Wakamatsu,T. et al.
Synthetic Communications, 1978 , vol. 8, p. 319 - 326
反应条件
1: 41 percent / ethanol; diethyl ether / 72 h / -2 °C
2: 72 percent / dimethylsulfoxide / 3 h / 50 °C
3: 30percent aq.H2SO4 / aq. acetic acid / 16 h / Heating
4: 58 g / p-toluenesulfonic acid / benzene / 6 h / Heating
View Scheme
参考文献
Lapitskaya, M. A.; Manukina, T. A.; Nozdracheva, A. T.; Sheimina, L. G.; Pivnitskii, K. K.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 261 - 265
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 2 p. 294 - 299
反应条件
1: 72 percent / dimethylsulfoxide / 3 h / 50 °C
2: 30percent aq.H2SO4 / aq. acetic acid / 16 h / Heating
3: 58 g / p-toluenesulfonic acid / benzene / 6 h / Heating
View Scheme
参考文献
Lapitskaya, M. A.; Manukina, T. A.; Nozdracheva, A. T.; Sheimina, L. G.; Pivnitskii, K. K.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 261 - 265
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 2 p. 294 - 299
反应条件
1: 78 percent / methanol; diethyl ether
2: 96 percent / silver acetate, glacialacetic acid, zinc powder (activated by HCl) / methanol / 24 h / 60 °C
View Scheme
参考文献
Naora, Hirokazu; Ohnuki, Takashi; Nakamura, Asao
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 7 p. 2401 - 2404
反应条件
1: 82 percent / sodium ethoxide / toluene / 0.5 h / Heating
2: 70 percent / PCl3 / CHCl3 / 5 h / Heating
3: 62 percent / zinc-silver couple / methanol / 48 h / Ambient temperature
View Scheme
参考文献
Novak; Baan; Marosfalvi; Szantay
Chemische Berichte, 1980 , vol. 113, # 9 p. 2939 - 2949
反应条件
1: 70 percent / PCl3 / CHCl3 / 5 h / Heating
2: 62 percent / zinc-silver couple / methanol / 48 h / Ambient temperature
View Scheme
参考文献
Novak; Baan; Marosfalvi; Szantay
Chemische Berichte, 1980 , vol. 113, # 9 p. 2939 - 2949
反应条件
1: 70 percent / polyphosphoric acid / 2.5 h / 100 °C
2: 22.5 g / 15percent methanolic HCl / 30 h / Ambient temperature
View Scheme
参考文献
Thakur, S. B.; Jadhav, K. S.; Bhattacharyya, S. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 675 - 683
反应条件
1: 1.) H2SO4, H2O2 (28percent w/v), 2.) NaOH / 1.) 40 deg C, 8 h, 2.) MeOH, water, reflux, 5 h
2: 52.5 g / 5percent methanolic HCl / 48 h / Ambient temperature
3: 38 g / NaIO4 / ethanol; H2O / 1 h / 35 °C
4: 101 g / pyridine / 1.) RT, 24 h, 2.) reflux, 4 h
5: 40 g / 10percent aq. NaOH / 4 h / Heating
6: 55 percent / 60percent H2SO4 / 2.5 h / 130 °C
7: 70 percent / polyphosphoric acid / 2.5 h / 100 °C
8: 22.5 g / 15percent methanolic HCl / 30 h / Ambient temperature
View Scheme
参考文献
Thakur, S. B.; Jadhav, K. S.; Bhattacharyya, S. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 675 - 683
反应条件
1: 38 g / NaIO4 / ethanol; H2O / 1 h / 35 °C
2: 101 g / pyridine / 1.) RT, 24 h, 2.) reflux, 4 h
3: 40 g / 10percent aq. NaOH / 4 h / Heating
4: 55 percent / 60percent H2SO4 / 2.5 h / 130 °C
5: 70 percent / polyphosphoric acid / 2.5 h / 100 °C
6: 22.5 g / 15percent methanolic HCl / 30 h / Ambient temperature
View Scheme
参考文献
Thakur, S. B.; Jadhav, K. S.; Bhattacharyya, S. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 675 - 683
反应条件
1: 9.8 g / pyridine
2: 7.8 g / NaOH/85percent aq. MeOH / 2.5 h / Heating
3: 6.2 g / Jones' reagent / acetone / 0.5 h / 0 - 5 °C
4: 8.7 g / Br2 / CCl4 / 2 h / Ambient temperature
5: 6.1 g / NaOH / H2O / 6 h / Heating
6: 22.5 g / 15percent methanolic HCl / 30 h / Ambient temperature
View Scheme
参考文献
Thakur, S. B.; Jadhav, K. S.; Bhattacharyya, S. C.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 675 - 683
